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Prestigious award from the International Society of Hypertension to Italian Clinical Study
The International Society of Hypertension, ISH, met in Seoul (South Korea) on 29 September, and awarded the prestigious “Gold Award for best clinical study” to the Italian study on reducing arterial blood pressure in patients suffering from hypertension by regularly adding Grana Padano PDO to their diet.
The award-winning clinical study (called “Antihypertensive effect of milk-derivative tripeptides. Randomized, double-blind, placebo-controlled study on the effects of Grana Padano cheese PDO. in hypertensive patients”) had been conducted by the Hypertension Unit at Guglielmo da Saliceto Hospital in Piacenza, led by Dr Giuseppe Crippa, and the Institute of Food and Feed Science and Nutrition at Università Cattolica del Sacro Cuore in Piacenza.
The International Society of Hypertension, ISH, is an official partner of the World Health Organization and the World Hypertension League. The meeting of the International Society of Hypertension takes place bi-annually and, with its 5,000 delegates from all over the world, is one of the most important international events in the field of arterial hypertension. The Italian clinical study was selected from a shortlist of approximately 2,000 studies.
The work coordinated by Dr Giuseppe Crippa involved adding, for two months, into the daily diet of 30 patients affected by hypertension, 30 grams of Grana Padano PDO cheese aged 12 months (as it is particularly rich in tripeptides, which have ace-inhibitor properties). The same patients, in random order, took an inactive placebo, free of peptides, over the same 2-month period.
“I’m very pleased to have received this prestigious award”, commented Dr Crippa, “which rewards the accuracy of our research, conducted with a methodology normally used in clinical intervention studies to test the efficacy of pharmaceuticals. The design used for our study (double-blind, randomized, with placebo) is rarely used to evaluate the efficacy of functional foods such as Grana Padano. I think it’s excellent news to learn that, in order to lower blood pressure when it’s too high, you can get some help from food as well”.
“I think the judges favoured this study for at least two reasons”, added Dr Crippa, “first, the applicability of the results in daily clinical practice, since adding 30 grams of Grana Padano to one’s diet is easy to do, as this is an easy ingredient to find. Additionally, the method used to assess the hypertensive effects was especially accurate. Arterial blood pressure was measured using conventional means, as well as automated office blood pressure (AOBP) and 24-hour ambulatory blood pressure monitoring (ABPM). The assessment on the efficacy of the treatment is therefore based on over 350 blood pressure measurements for each patient evaluated in the study. One additional important clinical datum is that adding Grana Padano to the diet did not alter body weight, blood sugar, cholesterol or triglyceride levels in the patients examined”.
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